Claudio Roncoli Technical University of Crete The deployment of vehicle automation and communication systems (VACS) may lead to improvements in traffic management efficiency because of the novel possibilities of using VACS both as sensors and as actuators, as well as of a variety of new communications channels (vehicle-to-vehicles, vehicle-to-infrastructure) and related opportunities. This presentation aims at describing a model predictive control framework that can be utilised for the real-time coordinated and integrated control of a motorway system, considering that an amount of vehicles are equipped with specific VACS. The concept employs and exploits the synergistic (integrated) action of a number of old and new control measures, including ramp metering, vehicle speed control, and lane changing control at a macroscopic level.