ChIP-exo is a laboratory protocol used to identify the location of protein binding sites on DNA, with applications to the study of cancer and immune function. However, few methods exist for assessing the reproducibility of ChIP-exo data between different replicates in the same experiment. We used Euclidean distance to produce a reproducibility score for each potential binding event, determining a relationship between reproducibility and the presence of sequence motifs, as well as exploring ways to classify replicated events according to their reproducibility.