Online retailing presents a new business model with new operational challenges. Online retail inventory management and order fulfillment involves a series of interdependent decisions that include: deciding in which fulfillment centers (FCs) to place an item, determining how much inventory to hold, selecting the FC(s) from which to fulfill each order and deciding the timing, mode and routing of each shipment. In this talk we present an overview of the issues and a synopsis of some ongoing research.