PDE-constrained optimization is an essential technology for product development at The Boeing Company. This talk will survey three separate applications of increasing mathematical and computational complexity. The first application is a relatively straightforward parametric surface lofting application. The second application is structural analysis. In practice, there are at least three ways in which PDE-constrained optimization can be carried out, and these three approaches will all be reviewed. Finally, optimization of full airplane configurations can be performed in which the optimization problem can be viewed as a collection of coupled analysis problems, several of which can involve PDEs.